ISSN 2147-9720 | E-ISSN 2148-4279
Original Article
Ischemia-hyperpnea test is useful to detect patients with fibromyalgia syndrome
1 Department of Rheumatology, Division of Experimental and Clinical Medicine, Florence University, Firenze, Italy  
2 Department of Neurology and Psychiatry, Division of Neurophysiology, Careggi Hospital (AOUC), Florence, Italy  
Eur J Rheumatol 2015; 2: 89-95
DOI: 10.5152/eurjrheum.2015.0094
Key Words: Fibromyalgia syndrome, ıschemia-hyperpnea test, neuromuscular hyperexcitability, quality of life, fatigue

Objective: To demonstrate the prevalence of neuromuscular hyperexcitability in Fibromyalgia Syndrome (FMS) by electromyography ischaemia-hyperpnea test (IHT) and its correlation with clinical and clinimetric parameters.


Material and Methods: One hundred and forty-five FMS patients underwent IHT to evaluate neuromuscular hyperexcitability and were evaluated for pain (numeric Rating Scale and Regional Pain Scale), tenderness (tender points), disability [Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire (HAQ)], quality of life (QOL) [Short Form 36 (SF36)], mood [Hospital Anxiety and Depression Scale (HADS)], sleep [numeric rating scale (NRS)], and fatigue [Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT)].


Results: Of the 145 patients, 95 were tested positive by IHT, and 33 and 17 patients were negative and borderline, respectively. By comparing the three groups, IHT positive patients had lower age and lower SF36 vitality (V), social activities (SA), and mental summary index (MSI) than negative patients (p<0.05). By comparing positive versus negative patients and by comparing positive and borderline patients versus negative patients, it was found that FACIT was higher, whereas age, SF36 V, SA, mental health (MH), and MSI were lower (p<0.05).



Conclusion: FMS patients present a high prevalence of neuromuscular hyperexcitability, as assessed by IHT. IHT positive patients have poor QOL and higher fatigue than IHT negative patients. Thus, IHT positivity could identify FMS patients with a more severe disease.  

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