European Journal of Rheumatology
Invited Review

Systemic sclerosis: To subset or not to subset, that is the question


Toronto Scleroderma Program, Department of Medicine, Mount Sinai Hospital, Toronto Western Hospital, Toronto, Ontario, Canada


Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada


Department of Rheumatology, St. Maartenskliniek and Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands


Division of Rheumatology AOUC, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy


Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

Eur J Rheumatol 2020; 7: Supplement S222-S227
DOI: 10.5152/eurjrheum.2020.19116
Read: 290 Downloads: 135 Published: 06 August 2020

Systemic sclerosis (SSc) is a heterogeneous disease with variability in autoantibody profiles, skin and internal organ involvement, disease trajectory, and survival. The ability to identify more homogeneous subsets of SSc patients has informed patient care and been an essential aspect of SSc research. In this article, the historic evolution of subsetting systems in SSc are described including clinically based SSc subsetting systems, their utility, strengths, and limitations. There is a shifting paradigm of SSc subsets, including biologic classification of SSc subsets and fully data-driven approaches to SSc subset classification, taking into consideration the needs of the SSc global community in the modern era and the ability to prognosticate patients with SSc.

Cite this article as: Johnson SR, van den Hoogen F, Devakandan K, Matucci-Cerinic, Pope JE. Systemic sclerosis: To subset or not to subset, that is the question. Eur J Rheumatol 2020; 7(Suppl 3): S222-7.

EISSN 2148-4279